Custom Microspheres and nanoparticles

We offer custom synthesis of polymer microspheres and nanospheres to support your application needs.  Customers may select the material type, particle size, size distribution, color dye,  fluorescent dye, and/or surface functional groups such as carboxyl or amine groups.

We can encapsulate proteins, steroids, ligands, nucleic acids, drug molecules and other agents.  Additionally, we can coat the surface of your microspheres or nanoparticles with ligands, oligonucleotides, and other agents. 

For example, we have worked closely with clients in the past to:

• Vary PLGA monomer ratios, molecular weight, and surface characteristics to give the desired degradation rate or drug release profile
• Optimize targeted drug delivery by attaching ligands, peptides, oligonucleotides and other agents to microsphere and nanoparticle surfaces
• Tightly control microsphere and nanoparticle nominal particle size and size distribution
• Create nanoparticles under aseptic conditions for use in clinical trials with cGMP documentation
• Encapsulate both water-soluble and insoluble drugs into nano- and microspheres with modified surface charge to promote cell entry.  Fluorescence may also be incorporated for labeling of particles.
  

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